pharmacy scholarship: rachel crouch

crouch rd, beers jl, jackson kd. case study 11: considerations for enzyme mapping experiments-interaction between the aldehyde oxidase inhibitor hydralazine and glutathione. methods mol biol. 2021;2342:809-823. doi:10.1007/978-1-0716-1554-6_30

han sh, goins cm, arya t, shin wj, maw j, hooper a, sonawane dp, porter mr, bannister be, crouch rd, lindsey a a, lakatos g, martinez sr, alvarado j, akers ws, wang ns, jung ju, macdonald jd, stauffer sr. structure-based optimization of ml300-derived, noncovalent inhibitors targeting the severe acute respiratory syndrome coronavirus 3cl protease (sars-cov-2 3cl(pro)). j med chem. 2021;doi:10.1021/acs.jmedchem.1c00598

bissada je, truong v, abouda aa, wines kj, crouch rd, jackson kd. interindividual variation in cyp3a activity influences lapatinib bioactivation. drug metab dispos. 2019;47(11):1257. doi: 10.1124/dmd.119.088823

crouch rd, hutzler jm, daniels js. a novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry. xenobiotica. 2018;48(3):219-231. doi: 10.1080/00498254.2017.1296208

crouch rd, blobaum al, felts as, conn pj, lindsley cw. species-specific involvement of aldehyde oxidase and xanthine oxidase in the metabolism of the pyrimidine-containing mglu5-negative allosteric modulator vu0424238 (auglurant). drug metab dispos. 2017;45(12):1245-1259. doi: 10.1124/dmd.117.077552

crouch rd, morrison rd, byers fw, lindsley cw, emmitte ka, daniels js. evaluating the disposition of a mixed aldehyde oxidase/cytochrome p450 substrate in rats with attenuated p450 activity. drug metab dispos. 2016;44(8):1296-1303. doi: 10.1124/dmd.115.068338