sarah graff
assistant professor of pharmacy
research interests
- changes in pancreatic ion channel expression during exercise and how that, in turn, regulates glucose homeostasis.
publications & presentations
2023
sarah m. graff, arya y. nakhe, prasanna k. dadi, matthew t. dickerson, karolina e. zaborska, chloe e. ibsen, regan butterworth, and david a. jacobson. talk-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet. submitted to cell reports.
2021
sarah m. graff, stephanie r. johnson, paul j. leo, prasanna k. dadi, arya y. nakhe, aideen m. mcinerney-leo, mhairi marshall, matthew a. brown, david a. jacobson, emma l. duncan. a novel mutation in kcnk16 causing a gain-of-function in the talk-1 potassium channel: a new cause of maturity-onset diabetes of the young. jci insight. 2021; pubmed pmid: 34032641
2020
karolina e zaborska, prasanna k dadi, matthew t dickerson, arya y nakhe, ariel s thorson, charles m schaub, sarah m graff, jade e stanley, roy s kondapavuluru, jerod s denton, david a jacobson. lactate activation of α-cell k atp channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing ca2+ entry. molecular metabolism. 2020; pubmed pmid: 32736089
matthew t dickerson, prasanna k dadi, regan b butterworth, arya y nakhe, sarah m graff, karolina e zaborska, charles m schaub, david a jacobson. tetraspanin-7 regulation of l-type voltage-dependent calcium channels controls pancreatic β-cell insulin secretion. the journal of physiology, 2020; pubmed pmid: 32790176
xiaodun yang, sarah m. graff, kung-hsien ho, ruiying hu, gregory david, david a. jacobson, irina kaverina, christopher v. e. wright, ken lau, guoqiang gu. co-repressor sin3a is required for postnatal β-cell function and survival in mice. diabetes. 2020; pubmed pmid: 32245798
2018
m. t. dickerson, a. m. bogart, m. k. altman, s. c. milian, p. k. dadi, and d. a. jacobson. cytokine-mediated changes in k+ channel activity promotes an adaptive ca2+ response that sustains β-cell insulin secretion during inflammation. scientific reports. 2018; pubmed pmid: 29348619
2017
dickerson m, vierra n, milian s, dadi p, jacobson da. osteopontin activates the diabetes-associated potassium channel talk-1 in pancreatic β-cells. plos one. 2017; 12(4). pubmed pmid: 284031695
n. c. vierra, m. t. dickerson, p. k. dadi, k. l. jordan, k.a. kadare, m. k. altman, s. c. milian, and d. a. jacobson. talk-1 facilitation of er calcium leak controls delta-cell calcium handling and somatostatin secretion. molecular metabolism. 2017; pubmed pmid: 29402588
vierra n, dadi p, milian s, dickerson m, jordan k, gilon p, jacobson da. talk-1 channels control β cell endoplasmic reticulum ca2+ homeostasis. science signaling. 2017; 10(497). pubmed pmid:28928238