copyright (c) 2024 世界杯2022预选赛录像回放 all rights reserved. https://digitalcollections.lipscomb.edu/pharm_faculty recent documents in faculty works en-us mon, 26 aug 2024 12:10:22 pdt 3600 https://digitalcollections.lipscomb.edu/pharm_faculty/2 https://digitalcollections.lipscomb.edu/pharm_faculty/2 mon, 08 apr 2024 10:20:42 pdt the use of plant-based medicine dates back centuries, and cannabis (cannabis sativa) is one such plant that has been used medicinally and illicitly. although cannabis contains hundreds of cannabinoids and other natural products, its potential medicinal use was largely ignored by modern researchers due to the legal restrictions and heavy regulations introduced in the 1930s. as restrictions on cannabis access have eased since the 1990s there is renewed interest in the research of cannabinoids and the other components in the cannabis plant. the focus of this review article is an overview of cannabis and the analytical challenges in the quality control and biological analysis. the pharmacological effects of psychoactive cannabinoids, delta-9-tetrahydrocannabinol (Δ9-thc) and delta-8-trans- tetrahydrocannabinol (Δ8-thc) is discussed, along with an abundant non-intoxicating cannabinoid, cannabidiol (cbd). the analytical methods for the quality control assays of cannabis products include gas chromatography and liquid chromatography coupled to different detectors, including mass spectrometry. this review will highlight various analytical methods for the quality control of cannabis products and the quantitation of cannabinoids in biological matrices for forensics and toxicology.

]]> matt j. vergne et al. https://digitalcollections.lipscomb.edu/pharm_faculty/1 https://digitalcollections.lipscomb.edu/pharm_faculty/1 mon, 19 feb 2024 07:35:03 pst this laboratory experiment introduces upper-division undergraduate analytical chemistry students to liquid chromatography-tandem mass spectrometry (lc-ms/ms) in a forensic application: the analysis of cocaine and metabolites of cocaine in simulated serum ostensibly from drug overdose victims. for this investigation, students developed the analytical methods. first, the students determined the multiple reaction monitoring (mrm) transitions and optimized collision energy. the ms methods developed were then added to an lc method for lc-ms/ms quantitation with a 2.5 min run time. students successfully quantified the drugs and metabolites, and they were able to identify which samples indicated cocaine use and overdose

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